diff --git a/packages/@adobe/react-spectrum/stories/listbox/ListBox.stories.tsx b/packages/@adobe/react-spectrum/stories/listbox/ListBox.stories.tsx
index e7665965644..2b6375a0bd9 100644
--- a/packages/@adobe/react-spectrum/stories/listbox/ListBox.stories.tsx
+++ b/packages/@adobe/react-spectrum/stories/listbox/ListBox.stories.tsx
@@ -476,6 +476,26 @@ export const WithDisabledOptions: ListBoxStory = {
   name: 'with disabled options'
 };
 
+export const DisabledListBox: ListBoxStory = {
+  render: () => (
+    <ListBox flexGrow={1} aria-labelledby="label" items={withSection} isDisabled>
+      {item => (
+        <Section key={item.name} items={item.children} title={item.name}>
+          {item => <Item key={item.name}>{item.name}</Item>}
+        </Section>
+      )}
+    </ListBox>
+  ),
+  decorators: [
+    Story => (
+      <StoryDecorator>
+        <Story />
+      </StoryDecorator>
+    )
+  ],
+  name: 'disabled ListBox'
+};
+
 export const StaticWithDisabledOptions: ListBoxStory = {
   render: () => (
     <ListBox flexGrow={1} aria-labelledby="label" disabledKeys={['3', '5']}>
diff --git a/packages/@adobe/react-spectrum/test/listbox/ListBox.test.js b/packages/@adobe/react-spectrum/test/listbox/ListBox.test.js
index 6704bf6d6eb..354d0231093 100644
--- a/packages/@adobe/react-spectrum/test/listbox/ListBox.test.js
+++ b/packages/@adobe/react-spectrum/test/listbox/ListBox.test.js
@@ -358,6 +358,27 @@ describe('ListBox', function () {
       fireEvent.keyDown(listbox, {key: 'ArrowUp', code: 38, charCode: 38});
       expect(document.activeElement).toBe(options[0]);
     });
+
+    it('supports disabling the entire listbox', async function () {
+      let user = userEvent.setup({delay: null, pointerMap});
+      let tree = renderComponent({
+        onSelectionChange,
+        selectionMode: 'single',
+        isDisabled: true,
+        autoFocus: 'first'
+      });
+      let listbox = tree.getByRole('listbox');
+      let options = within(listbox).getAllByRole('option');
+
+      expect(listbox).toHaveAttribute('aria-disabled', 'true');
+      for (let option of options) {
+        expect(option).toHaveAttribute('aria-disabled', 'true');
+      }
+
+      await user.click(options[1]);
+      expect(onSelectionChange).toHaveBeenCalledTimes(0);
+      expect(document.activeElement).toBe(listbox);
+    });
   });
 
   describe('supports multi selection', function () {
diff --git a/packages/react-aria-components/test/ListBox.test.js b/packages/react-aria-components/test/ListBox.test.js
index 80410f975de..5da388fada5 100644
--- a/packages/react-aria-components/test/ListBox.test.js
+++ b/packages/react-aria-components/test/ListBox.test.js
@@ -698,6 +698,31 @@ describe('ListBox', () => {
     expect(document.activeElement).toBe(items[2]);
   });
 
+  it('should support isDisabled prop on the ListBox', async () => {
+    let onSelectionChange = jest.fn();
+    let {getByRole, getAllByRole} = render(
+      <ListBox
+        aria-label="Test"
+        selectionMode="multiple"
+        isDisabled
+        onSelectionChange={onSelectionChange}>
+        <ListBoxItem id="cat">Cat</ListBoxItem>
+        <ListBoxItem id="dog">Dog</ListBoxItem>
+        <ListBoxItem id="kangaroo">Kangaroo</ListBoxItem>
+      </ListBox>
+    );
+
+    let listbox = getByRole('listbox');
+    let items = getAllByRole('option');
+    expect(listbox).toHaveAttribute('aria-disabled', 'true');
+    for (let item of items) {
+      expect(item).toHaveAttribute('aria-disabled', 'true');
+    }
+
+    await user.click(items[1]);
+    expect(onSelectionChange).not.toHaveBeenCalled();
+  });
+
   it.each`
     interactionType
     ${'mouse'}
diff --git a/packages/react-aria/src/listbox/useListBox.ts b/packages/react-aria/src/listbox/useListBox.ts
index 14185b14f5a..409ecb9cf29 100644
--- a/packages/react-aria/src/listbox/useListBox.ts
+++ b/packages/react-aria/src/listbox/useListBox.ts
@@ -36,6 +36,8 @@ import {useLabel} from '../label/useLabel';
 import {useSelectableList} from '../selection/useSelectableList';
 
 export interface ListBoxProps<T> extends CollectionBase<T>, MultipleSelection, FocusEvents {
+  /** Whether the listbox is disabled. */
+  isDisabled?: boolean;
   /** Whether to auto focus the listbox or an option. */
   autoFocus?: boolean | FocusStrategy;
   /** Whether focus should wrap around when the end/start is reached. */
@@ -150,7 +152,7 @@ export function useListBox<T>(
     ref,
     selectionManager: state.selectionManager,
     collection: state.collection,
-    disabledKeys: state.disabledKeys,
+    disabledKeys: props.isDisabled ? new Set(state.collection.getKeys()) : state.disabledKeys,
     linkBehavior
   });
 
@@ -164,6 +166,7 @@ export function useListBox<T>(
   let id = useId(props.id);
   listData.set(state, {
     id,
+    isDisabled: props.isDisabled,
     shouldUseVirtualFocus: props.shouldUseVirtualFocus,
     shouldSelectOnPressUp: props.shouldSelectOnPressUp,
     shouldFocusOnHover: props.shouldFocusOnHover,
@@ -194,6 +197,7 @@ export function useListBox<T>(
         : {},
       {
         role: 'listbox',
+        'aria-disabled': props.isDisabled || undefined,
         'aria-orientation': orientation,
         ...mergeProps(fieldProps, listProps)
       }
diff --git a/packages/react-aria/src/listbox/useOption.ts b/packages/react-aria/src/listbox/useOption.ts
index dbab6edf899..a9896fc1043 100644
--- a/packages/react-aria/src/listbox/useOption.ts
+++ b/packages/react-aria/src/listbox/useOption.ts
@@ -107,7 +107,7 @@ export function useOption<T>(
 
   let data = listData.get(state);
 
-  let isDisabled = props.isDisabled ?? state.selectionManager.isDisabled(key);
+  let isDisabled = props.isDisabled ?? (data?.isDisabled || state.selectionManager.isDisabled(key));
   let isSelected = props.isSelected ?? state.selectionManager.isSelected(key);
   let shouldSelectOnPressUp = props.shouldSelectOnPressUp ?? data?.shouldSelectOnPressUp;
   let shouldFocusOnHover = props.shouldFocusOnHover ?? data?.shouldFocusOnHover;
diff --git a/packages/react-aria/src/listbox/utils.ts b/packages/react-aria/src/listbox/utils.ts
index 022c74e5afb..f61c7751a4e 100644
--- a/packages/react-aria/src/listbox/utils.ts
+++ b/packages/react-aria/src/listbox/utils.ts
@@ -15,6 +15,7 @@ import {ListState} from 'react-stately/useListState';
 
 interface ListData {
   id?: string;
+  isDisabled?: boolean;
   shouldSelectOnPressUp?: boolean;
   shouldFocusOnHover?: boolean;
   shouldUseVirtualFocus?: boolean;