diff --git a/src/__tests__/config.test.ts b/src/__tests__/config.test.ts
index 6949f3a6a..1fb2cc51d 100644
--- a/src/__tests__/config.test.ts
+++ b/src/__tests__/config.test.ts
@@ -22,6 +22,7 @@ test('configure() overrides existing config values', () => {
     asyncUtilTimeout: 5000,
     defaultDebugOptions: { message: 'debug message' },
     defaultIncludeHiddenElements: false,
+    disabledEventWarning: true,
   });
 });
 
diff --git a/src/__tests__/fire-event.test.tsx b/src/__tests__/fire-event.test.tsx
index ea39223ac..becf3ec0f 100644
--- a/src/__tests__/fire-event.test.tsx
+++ b/src/__tests__/fire-event.test.tsx
@@ -14,6 +14,8 @@ import {
 } from 'react-native';
 
 import { fireEvent, render, screen } from '..';
+import { configure, resetToDefaults } from '../config';
+import { logger } from '../helpers/logger';
 import { nativeState } from '../native-state';
 
 const layoutEvent = { nativeEvent: { layout: { width: 100, height: 100 } } };
@@ -560,6 +562,17 @@ test('fireEvent handles handler that throws gracefully', async () => {
 });
 
 describe('disabled elements', () => {
+  let warnSpy: jest.SpyInstance;
+
+  beforeEach(() => {
+    warnSpy = jest.spyOn(logger, 'warn').mockImplementation(() => {});
+  });
+
+  afterEach(() => {
+    warnSpy.mockRestore();
+    resetToDefaults();
+  });
+
   test('does not fire on disabled Pressable', async () => {
     const onPress = jest.fn();
     await render(
@@ -623,6 +636,61 @@ describe('disabled elements', () => {
     await fireEvent.press(screen.getByText('Trigger Test'));
     expect(handlePress).toHaveBeenCalledTimes(1);
   });
+
+  test('warns when firing an event on a disabled element', async () => {
+    await render(
+      <Pressable onPress={jest.fn()} disabled={true}>
+        <Text>Trigger</Text>
+      </Pressable>,
+    );
+
+    await fireEvent.press(screen.getByText('Trigger'));
+
+    expect(warnSpy).toHaveBeenCalledTimes(1);
+    expect(warnSpy.mock.calls[0][0]).toMatchInlineSnapshot(`
+      "Tried to fire the "press" event on a disabled element, so no handler was called.
+      If this is intentional, you can disable this warning via \`configure({ disabledEventWarning: false })\`."
+    `);
+  });
+
+  test('does not warn when the event bubbles to an enabled parent', async () => {
+    await render(
+      <Pressable onPress={jest.fn()}>
+        <Pressable onPress={jest.fn()} disabled={true}>
+          <Text>Inner Trigger</Text>
+        </Pressable>
+      </Pressable>,
+    );
+
+    await fireEvent.press(screen.getByText('Inner Trigger'));
+
+    expect(warnSpy).not.toHaveBeenCalled();
+  });
+
+  test('does not warn when the element is not disabled (e.g. pointerEvents="none")', async () => {
+    await render(
+      <View pointerEvents="none">
+        <Pressable testID="btn" onPress={jest.fn()} />
+      </View>,
+    );
+
+    await fireEvent.press(screen.getByTestId('btn'));
+
+    expect(warnSpy).not.toHaveBeenCalled();
+  });
+
+  test('does not warn when disabledEventWarning is turned off', async () => {
+    configure({ disabledEventWarning: false });
+    await render(
+      <Pressable onPress={jest.fn()} disabled={true}>
+        <Text>Trigger</Text>
+      </Pressable>,
+    );
+
+    await fireEvent.press(screen.getByText('Trigger'));
+
+    expect(warnSpy).not.toHaveBeenCalled();
+  });
 });
 
 describe('pointerEvents prop', () => {
@@ -831,6 +899,16 @@ describe('non-editable TextInput', () => {
 });
 
 describe('responder system', () => {
+  let warnSpy: jest.SpyInstance;
+
+  beforeEach(() => {
+    warnSpy = jest.spyOn(logger, 'warn').mockImplementation(() => {});
+  });
+
+  afterEach(() => {
+    warnSpy.mockRestore();
+  });
+
   test('respects disabled prop through composite wrappers', async () => {
     function TestChildTouchableComponent({
       onPress,
diff --git a/src/config.ts b/src/config.ts
index b910b40d8..cf3977784 100644
--- a/src/config.ts
+++ b/src/config.ts
@@ -12,6 +12,12 @@ export type Config = {
   /** Default value for `includeHiddenElements` query option. */
   defaultIncludeHiddenElements: boolean;
 
+  /**
+   * Warn when an event is fired on a disabled element and no handler is
+   * triggered as a result. Set to `false` to opt out.
+   */
+  disabledEventWarning: boolean;
+
   /** Default options for `debug` helper. */
   defaultDebugOptions?: Partial<DebugOptions>;
 };
@@ -24,6 +30,7 @@ export type ConfigAliasOptions = {
 const defaultConfig: Config = {
   asyncUtilTimeout: 1000,
   defaultIncludeHiddenElements: false,
+  disabledEventWarning: true,
 };
 
 let config = { ...defaultConfig };
@@ -37,6 +44,7 @@ export function configure(options: Partial<Config & ConfigAliasOptions>) {
     defaultDebugOptions,
     defaultHidden,
     defaultIncludeHiddenElements,
+    disabledEventWarning,
     ...rest
   } = options;
 
@@ -50,6 +58,7 @@ export function configure(options: Partial<Config & ConfigAliasOptions>) {
     asyncUtilTimeout: asyncUtilTimeout ?? config.asyncUtilTimeout,
     defaultDebugOptions,
     defaultIncludeHiddenElements: resolvedDefaultIncludeHiddenElements,
+    disabledEventWarning: disabledEventWarning ?? config.disabledEventWarning,
   };
 }
 
diff --git a/src/fire-event.ts b/src/fire-event.ts
index 4b64b652c..b76e6f9b1 100644
--- a/src/fire-event.ts
+++ b/src/fire-event.ts
@@ -8,12 +8,15 @@ import type {
 import type { Fiber, TestInstance } from 'test-renderer';
 
 import { act } from './act';
+import { getConfig } from './config';
 import type { LayoutRectangle } from './event-builder';
 import { buildLayoutEvent, buildScrollEvent, buildTouchEvent } from './event-builder';
 import type { EventHandler } from './event-handler';
 import { getEventHandlerFromProps } from './event-handler';
+import { computeAriaDisabled } from './helpers/accessibility';
 import { isInstanceMounted } from './helpers/component-tree';
 import { isHostScrollView, isHostTextInput } from './helpers/host-component-names';
+import { logger } from './helpers/logger';
 import { isPointerEventEnabled } from './helpers/pointer-events';
 import { isEditableTextInput } from './helpers/text-input';
 import { nativeState } from './native-state';
@@ -113,6 +116,51 @@ function findEventHandlerFromFiber(fiber: Fiber | null, eventName: string): Even
   return findEventHandlerFromFiber(fiber.return, eventName);
 }
 
+/**
+ * Walks up from the target to the nearest element that can respond to touches
+ * (a touch responder or a host `TextInput`), mirroring `findEventHandler`.
+ */
+function getNearestTouchResponder(instance: TestInstance): TestInstance | null {
+  let current: TestInstance | null = instance;
+  while (current != null) {
+    if (isTouchResponder(current)) {
+      return current;
+    }
+
+    current = current.parent;
+  }
+
+  return null;
+}
+
+/**
+ * Warns when an event did not trigger any handler because the responding
+ * element is disabled. Helps debug tests that silently do nothing.
+ * Can be opted out via `configure({ disabledEventWarning: false })`.
+ */
+function warnAboutDisabledEventTarget(instance: TestInstance, eventName: string) {
+  if (!getConfig().disabledEventWarning) {
+    return;
+  }
+
+  const target = getNearestTouchResponder(instance) ?? instance;
+
+  // `TextInput` editability (`editable={false}`) is a separate concern from
+  // disabled state, so we don't warn about it here to avoid false positives.
+  if (isHostTextInput(target)) {
+    return;
+  }
+
+  if (!computeAriaDisabled(target)) {
+    return;
+  }
+
+  logger.warn(
+    `Tried to fire the "${eventName}" event on a disabled element, so no handler was called.\n` +
+      'If this is intentional, you can disable this warning via `configure({ disabledEventWarning: false })`.',
+  );
+}
+
 // String union type of keys of T that start with on, stripped of 'on'
 type EventNameExtractor<T> = keyof {
   [K in keyof T as K extends `on${infer Rest}` ? Uncapitalize<Rest> : never]: T[K];
@@ -135,6 +183,7 @@ async function fireEvent(instance: TestInstance, eventName: EventName, ...data:
 
   const handler = findEventHandler(instance, eventName);
   if (!handler) {
+    warnAboutDisabledEventTarget(instance, eventName);
     return;
   }
 
diff --git a/website/docs/14.x/docs/api/misc/config.mdx b/website/docs/14.x/docs/api/misc/config.mdx
index a72fa8dea..f1b7eda3c 100644
--- a/website/docs/14.x/docs/api/misc/config.mdx
+++ b/website/docs/14.x/docs/api/misc/config.mdx
@@ -10,6 +10,9 @@ type Config = {
   /** Default value for `includeHiddenElements` query option. */
   defaultIncludeHiddenElements: boolean;
 
+  /** Warn when firing an event on a disabled element triggers no handler. */
+  disabledEventWarning: boolean;
+
   /** Default options for `debug` helper. */
   defaultDebugOptions?: Partial<DebugOptions>;
 };
@@ -32,6 +35,14 @@ Default value for [includeHiddenElements](/docs/api/queries#includehiddenelement
 
 This option is also available as `defaultHidden` alias for compatibility with [React Testing Library](https://testing-library.com/docs/dom-testing-library/api-configuration/#defaulthidden).
 
+### `disabledEventWarning` option
+
+When `fireEvent` is used on a disabled element (e.g. a `Pressable` with `disabled={true}`) the event is not dispatched to any handler, which can be surprising while debugging tests. When this option is enabled (the default), a warning is logged in that case. Set it to `false` to opt out:
+
+```ts
+configure({ disabledEventWarning: false });
+```
+
 ### `defaultDebugOptions` option
 
 Default [debug options](#debug) to be used when calling `debug()`. These default options will be overridden by the ones you specify directly when calling `debug()`.